Biomarkers of metabolic syndrome and its relationship with the zinc nutritional status in obese women.

INTRODUCTION: Obesity is a chronic disease that induces risk factors for metabolic syndrome and, is associated with disturbances in the metabolism of the zinc. Therefore, the aim of this study was to investigate the existence of relationship between the biomarkers of metabolic syndrome and the zinc nutricional status in obese women. METHOD: Seventy-three premenopausal women, aged between 20 and 50 years, were divided into two groups: case group, composed of obese (n = 37) and control group, composed of no obese (n = 36). The assessment of the body mass index and waist circumference were carried out using anthropometric measurements. The plasmatic and erythrocytary zinc were analyzed by method atomic absorption spectrophotometry (λ = 213.9 nm). RESULTS: In the study, body mass index and waist circumference were higher in obese women than control group (p < 0.05). The mean plasmatic zinc was 72.2 ± 9.0 µg/dl in obese women and 73.4 ± 8.5 µg/dl in control group (p > 0.05). The mean erythrocytary zinc was 36.4 ± 15.0 µg/gHb and 45.4 ± 14.3 µg/gHb in the obese and controls, respectively (p < 0.05). Regression analysis showed that the body mass index (t =-2.85) and waist circumference (t = -2.37) have a negative relationship only with the erythrocytary zinc (R² = 0.32, p < 0.05). CONCLUSIONS: The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations in erythrocytes. Regression analysis demonstrates that the erythrocytary zinc is influenced by biomarkers of the metabolic syndrome, presenting an inverse relationship with the waist circumference and body mass index.

Biomarkers of metabolic syndrome and its relationship with the zinc nutritional status in obese women / Biomarcadores del síndrome metabólico y su relación con el estado nutricional del zinc en mujeres obesas

Introduction: Obesity is a chronic disease that induces risk factors for metabolic syndrome and, is associated with disturbances in the metabolism of the zinc. Therefore, the aim of this study was to investigate the existence of relationship between the biomarkers of metabolic syndrome and the zinc nutricional status in obese women. Method: Seventy-three premenopausal women, aged between 20 and 50 years, were divided into two groups: case group, composed of obese (n = 37) and control group, composed of no obese (n = 36). The assessment of the body mass index and waist circumference were carried out using anthropometric measurements. The plasmatic and erythrocytary zinc were analyzed by method atomic absorption spectrophotometry (λ = 213.9 nm). Results: In the study, body mass index and waist circumference were higher in obese women than control group (p < 0.05). The mean plasmatic zinc was 72.2 ± 9.0 μg/dl in obese women and 73.4 ± 8.5 μg/dl in control group (p > 0.05). The mean erythrocytary zinc was 36.4 ± 15.0 μg/gHb and 45.4 ± 14.3 μg/gHb in the obese and controls, respectively (p < 0.05). Regression analysis showed that the body mass index (t =-2.85) and waist circumference (t = -2.37) have a negative relationship only with the erythrocytary zinc (R2 = 0.32, p < 0.05). Conclusions: The study shows that there are alterations in biochemical parameters of zinc in obese women, with low zinc concentrations in erythrocytes. Regression analysis demonstrates that the erythrocytary zinc is influenced by biomarkers of the metabolic syndrome, presenting an inverse relationship with the waist circumference and body mass index (AU)

Introducción: La obesidad es una enfermedad crónica que induce factores de riesgo del síndrome metabòlico y se asocia con trastornos en el metabolismo del zinc. Por lo tanto, este estudio investigó la relación entre biomarcadores del síndrome metabólico y el estado nutricional del zinc en mujeres obesas. 
Métodos: Se incluyeron 73 mujeres premenopáusicas, de 20 a 50 años de edad, que fueron divididos en dos grupos: grupo casos (obesos, n = 37) y grupo control (no obesos, n = 36). Evaluación del índice de masa corporal y la circunferencia de la cintura se realizó con variables antropométricas. El análisis del zinc plasmático y eritrocitario se realizó de acuerdo con el método de espectrofotometría de absorción atómica en llama (λ = 213,9 nm). Resultados: El zinc plasmático medio fue de 72,2 ± 9,0 μg/dL en las mujeres obesas y 73,4 ± 8,5 μg/dL en el grupo control (p > 0,05). Los valores medios de zinc eritrocitario fueron de 36,4 ± 15,0 μg/gHb en mujeres obesas y 45,4 ± 14,3 μg/gHb en controles (p < 0,05). En la regresión multivariable, el índice de masa corporal (t = -2,85) y la circunferencia de la cintura (t = -2,37) tiene una relación negativa con el zinc eritrocitario (R2 = 0,32, p < 0,05). Conclusiones: El estudio muestra que hay cambios en los parámetros del zinc en las mujeres obesas, con bajas concentraciones de zinc en los eritrocitos. Además, el análisis de regresión muestra que el zinc eritrocitario fue influenciado por los biomarcadores del síndrome metabólico, presentando una relación inversa con el índice de masa corporal y circunferencia de la cintura (AU)